researchers discover powerful anticancer in the soil of Castel del Monte. Not to forget a piece of the history of international medicine

L’Alta Murgia and the territory of the area of Castel del Monte continue to amaze, not only from the point of view historical but also in the field medical-scientific. In reality, the story we are about to tell you is nothing more than a memorandum since it is well known to experts and dates back to over 70 years ago. Let’s talk about discovery of a powerful one natural anticancer agent:

There daunorubicinalso known as daunomycinit’s a chemotherapy drug used to treat the cancer. Specifically, it is used for acute myeloid leukemia (LMA), the acute lymphoblastic leukemia (LLA), the chronic myeloid leukemia (LMC) and the Kaposi’s sarcoma. It is administered by injection into a vein. There is also a liposomal formulation known as liposomal daunorubicin. Perhaps, not everyone remembers that the discovery of him occurred in the land near Castel del Montein the territory of Andria: in the 1950s, an Italian research company, the Farmitalia Research Laboratories, I start research aimed at isolating anti-tumor compounds from soil microbes. The scientific initiative led researchers to isolate a piece of land from the surrounding area Castel del Montetoday a heritage UNESCO. This sampling of soil allowed the isolation of a new strain of Streptomyces – I Streptomyces peucetius – which produced a red pigment and from this bacterium a was produced antibiotic which turned out to have good activity against murine tumors. Since a group of French researchers discovered the same compound around the same time:

The two teams named the compound daunorubicincombining the name Daunia well-known pre-Roman civilization that occupied the area of ​​Italy where the compound was isolated, with the French word for ruby, rubiswhich describes color. ^{[fonte] [fonte] [fonte]} Clinical trials began in the 1960s and the drug was successful in treating acute leukemia and lymphoma. However, in 1967it was recognized that daunorubicin could produce cardiac toxicity fatal. Since then, daunorubicin has been used only for specific cases and more sparingly than in the past. This too is the history of our territory (as well as of Medicine). ^[fonte] In 2015-2016, a team from Ohio State University demonstrated that, “by carefully manipulating strands of viral DNA, it is possible to create an origami structure with complex folds in just 10 minutes. Incredibly, these structures are only 100 nanometers wide, or 1,000 times as small as the width of a human hair. Small volumes of daunorubicin can be packed into these tiny pods, which can then be released into an environment full of leukemia cells.”. ^[fonte]

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