Covid, vaccines and possible side effects, a topic that has been debated for a long time during the pandemic and continues to be done. Vaccines have contributed decisively to combating the virus throughout the world. Now a new study has been released, the largest ever carried out on the safety of vaccines, which analyzes the incidence of some adverse events such as thrombosis, pericarditis, myocarditis recorded on a basis of 99 million individuals vaccinated against Covid. This is the largest study ever carried out on anti-covid vaccines. Here is the data that emerged.
The global study on covid vaccines
The Global Vaccine Data Network (GVDN), thanks to the Global COVID Vaccine Safety project, evaluated the incidence rates of 13 conditions (cardiac, blood and neurological) comparing those that emerged after vaccination and those expected in the absence of the vaccine. Experts assessed how much the vaccines increased the risk of the conditions examined, hunting for what epidemiologists technically call “safety signals”.
«The size of the population in this study increased the possibility of identifying rare potential vaccine safety signals. Individual sites or regions are unlikely to have a population large enough to detect very rare signals,” explained Professor Kristýna Faksová from the Department of Epidemiological Research at the Statens Serum Institut in Copenhagen, Denmark, who led the study.
Anti-covid vaccines and adverse reactions
Among the adverse reactions analyzed in the study, which involved almost 100 million vaccinated people from eight countries, were myocarditis, pericarditis, Guillain-Barré syndrome; thrombosis of the cerebral venous sinus; transverse myelitis; acute disseminated encephalomyelitis and others. The 13 conditions were also related to the type of vaccine used, which means the adenoviral vector and the mRNA vaccine. Cross-referencing the enormous amount of data collected in this global analysis, it emerged that, within 42 days of vaccination, the risk was very similar to the background risk, i.e. that expected without vaccination in the general population, for most of the conditions examined. But with some significant differences, precisely by virtue of the enormous number of vaccinated people analyzed.
All the data from the anti-covid vaccine study
For example, 190 cases of Guillain-Barré syndrome were recorded in subjects who received a viral vector vaccine, compared to 66 expected without vaccination. As regards thrombosis of the cerebral venous sinus, after the first dose of the viral vector vaccine the researchers observed a risk more than 3 times higher than expected (69 cases against the expected 21). The risk of this condition also increased after an mRNA vaccine, equal to 1.49 times after the first dose and 1.25 times after the second. Acute disseminated encephalomyelitis showed a ratio of observed to expected cases of 3.78 (95% CI: 1.52, 7.78) after the first dose of an mRNA vaccine, with 7 cases detected versus 2 expected. Pericarditis and myocarditis increased with both types of vaccination. With an mRNA vaccine, the risk of pericarditis went from 1.74 times after the first dose to 2.64 times after the fourth dose. For myocarditis, the risk increased from 3.48 times after the first dose to 6.10 after the second with the same mRNA vaccine. This is statistically significant data, as highlighted by red in the study tables.
To date, as indicated by Ourworldindata, 13.57 billion doses of Covid vaccine have been administered and 70.6 percent of the world’s population has received at least one.
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