Meanwhile,
Air pollution linked mutations favor:
Air pollution is quantitatively linked to the onset of genetic mutations. Nevertheless, which favor lung cancer in non -smoking. Moreover, A new study published on Nature He identified in the DNA of people who had never smoked cellular alterations linked to exposure to smog. Similarly, the increase in the risk of lung cancer.
The key numbers of lung cancer – Air pollution linked mutations favor
- Every year in the world they are diagnosed 2.5 million new cases lung cancer. However,
- Cigarette smoke is the main cause of lung cancer. In addition, but a growing percentage, equal to 10-25%of the cases concerns people who have never smoked. Therefore, Almost always, lung tumors in this subgroup of patients are adenocarcinomas.
- Lung cancer represents the first cause of death linked to the world cancer. Meanwhile, Based on the air pollution linked mutations favor estimates of the Global Cancer Observatory developed in 2020 by Iarc. the International Agency for Cancer Research, in that year they died from lung cancer 1.8 million people.
- More than one million these deaths It occurs in China. where smoke, air pollution and other environmental pollution factors are present in an important way.
- In Italy. based on the estimates of the Airtum (Italian Association of Tumor Registers), they can develop a lung cancer in the course of life One in 10 men and one in 35 womenWhile One out of 11 and one in 45 women They risk dying because of the disease.
Lung cancer in non -smokers
The new search on Nature It could help to understand why. with the habit of smoking in decrease all over the world, an increasingly considerable slice of those who get sick of air pollution linked mutations favor lung cancer is made up of people who have never smoked.
Pollution. a mutagen agent
Many scientific studies have detected an epidemiological connection – that is, relating to the distribution and frequency with which the disease develops – between exposure to air pollution and the risk of getting sick of lung cancer. The new study Instead. it provides convincing genomic evidence which connect smog to the increase in pulmonary adenocarcinoma, the most common form of lung cancer.
A group of scientists coordinated by Ludmil Alexandrov. professor of cell medicine and molecular and bioengineering at the University of California in San Diego, analyzed the entire genetic code of lung tumors removed by 871 patients who had never smoked In Europe, North America, Africa and Asia, as part of the Sherlock-Lung studio (which aims to trace the causes of air pollution linked mutations favor lung cancer between non-smoking).
The signatures of air pollution on the DNA
By combining genomic data with estimates on past exposure to the air pollution of the participants. based on satellite and soil levels, scientists found that higher levels of polluted air in a region corresponded to a greater number of mutations that favored lung cancer in the participants.
Exposure to fine particulates (PM2.5) was for example linked to mutations on the TP53 gene Already in the past associated with cigarette smoke.
The mutations found were both direct (notes. that is, to directly promote the development of tumors) and simply linked to processes that can favor the environment suitable for a tumor, such as those of cellular aging. The people exposed to the highest levels of air pollution also had shorter telomersthe DNA protective strings air pollution linked mutations favor found at the ends of the chromosomes. that should protect them from damage. This feature is a signal of a Potentially faster cell divisiona fact that can encourage cancer.
Other risk factors
Air pollution therefore the number of somatic mutations increasesthat is. of those alterations that occur in any cell of the organism other than those of the germ line (oocytes and spermatozoa).
The study also identified only a slight increase in this type of mutations related to second hand smoke (a complex factor to be analyzed. because it is closely linked to the exposure time and at the distance from those who smoke); while it highlighted a significant increase in mutations related to the consumption of Chinese medicinal herbs containing Aristolochico acida substance already known to have a powerful carcinogenic effect.
(function() { var _fbq = window._fbq || (window._fbq air pollution linked mutations favor = []); if (!_fbq.loaded) { postTcfReady(startFb = function() { setTimeout(() => { mmLoader({ src: “//connect.facebook.net/en_US/fbds.js”, async: true }); }, 6000); _fbq.loaded = true; }) } })(); window._fbq = window._fbq || []; window._fbq.push([‘track’, ‘6018267402913’, {‘value’:’0.00′,’currency’:’EUR’}]);
Air pollution linked mutations favor
Further reading: Antonio Pellicer, pioneer of reproductive medicine: “When I meet a couple who want a son and she is more than 45 years old, the first speech I do is always on the complications of the pregnancy related to age” – Lamezia, 150 citizens involved in the screening day at the Impastato Park: ‘An open -air health pole’ – A renewed park between green areas, love paths and fitness zones – He arrives at the clinic of the Casa del Sole with a heart problem and the doctors save his life – ASL TO5: a new path for chronic kidney disease – Turin Chronicle.
